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The reduction in anxiety was similar (ondansetron -13 mm, promethazine -14 mm; difference -1 mm; 95% CI = -10 to 10 mm) Dicelgis (class a) was 0 so I'm on Phenergan (class c) as really needed only. While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy. What can I take in place of Zofran? Can I buy Zofran over-the-counter? I would personally never take phenergan during pregnancy, I would rather deal with the nausea than take the risk. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis more Prescription only. Baseline nausea, anxiety, and sedation scores were similar. Zofran does not show a serious side effect; on the other hand, Phenergan shows serious side effects. But you can actually take 4-8mg of zofran every 4-8 hours Regarding your concern I want to share with you that,Zofran contains , Ondansetron is an antiemetic (anti-nausea medicine). Side effects of Zofran and Phenergan that are similar include dizziness, drowsiness, constipation, and blurred vision. Heidi Fowler answered Psychiatry 26 years experience Drink it strong: Ginger can reduce nausea & upset stomach 26. For prophylactic administration zofran has better numbers. Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm). For evenings and in the middle of episodes, she takes Phenergan as she usually sleeps off episodes-- for her, it helps to abort more nausea better than Zofran when in the middle of an episode while helping her get to go to sleep faster and better than just waiting it out. Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. FWIW, she has cyclic vomiting syndrome with migraines from dysautonomia. Zofran, phernegan, reglan (metoclopramide) & their relations=anaphylaxis. 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Zofran can be used as tablets, dissolvable tablets, strips, and liquid. 6 / 5 average rating with 366 reviews forZofran. What is better for nausea Zofran or Reglan? While Phenergan contains Promethazine which is Antihistamine and also act ant vomiting agent Is it OK to take Zofran and Compazine together? While Phenergan contains Promethazine which is Antihistamine and also act ant vomiting agent Ondansetron is most often used to prevent nausea and vomiting caused by cancer chemotherapy and to prevent vomiting and nausea after surgery. As with any nausea medication, either need to be taken as soon as queasiness is noticed to be most effective One of the most effective anti-nausea medications is Zofran (ondansetron) which was developed to solve this problem. Promethazine is also used as an antihistamine and sedative. Ondansetron and promethazine belong to different drug classes Zofran is an antiemetic (anti-nausea and vomiting) and selective 5-HT3 receptor antagonist and Phenergan is an antihistamine. Conclusion The main conclusion of the above discussion is that Zofran and Phenergan belong to different drug groups, but they are used to treat nausea and vomiting. #2 Prochlorperazine ( Compazine ) It can be very helpful for mild nausea or if you take it after you take Zofran. I was given Zofran by IV in the ER in late January when I had my intestinal obstruction--it was also very effective, but I have never taken it in pill form. Ondansetron and promethazine are used to prevent nausea and vomiting. Evidence shows that the outcome at 30 minutes after administration the outcome between zofran and phenergan are equal for relief of nausea. When should you not take Zofran? 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